Hormone Therapy

An Introduction to Hormone
Pellet Therapy

Table of Contents

What Exactly Is Pellet Therapy?

You may have heard about pellet therapy, as it is widely considered the most physiologic and stable method for delivering hormones to both men and women. The pellets we use in our procedures are crafted from 100% bioidentical hormones, containing no additives, fillers, artificial ingredients, or preservatives.

Key Takeaways: Hormone Pellet Therapy

  • Hormone pellets are made from 100% bioidentical hormones with no additives or fillers and are about the size of a grain of cooked rice.
  • Placed just under the skin of the upper buttock, pellets dissolve slowly to provide a steady hormone release over about three to four months.
  • The release rate adapts to the body's needs, drawing more quickly when levels are low and more slowly when levels are closer to normal.
  • Dr. Varano and staff continuously evaluate dosing through regular testing, so intervals between appointments can vary by individual.

While we typically use testosterone pellets, estrogen pellets are also an option for select female patients. The pellets themselves are very small, about the size of a single grain of cooked rice. During the procedure, a tiny incision is made in the skin of the upper buttock area, and the pellets are placed just beneath the surface. From there, they dissolve slowly, providing a natural and steady release of hormones over a three to four-month period. With the pellets dissolving on their own, there is very little for the patient to manage or worry about.

How Does Pellet Therapy Work with Your Body?

Physiologically, the pellets work in harmony with your body’s needs. Rejection of the pellets is extremely rare across the thousands of successful procedures that have been performed.

The release rate adapts to your body’s requirements. For example, if a patient’s testosterone levels are particularly low, their body may draw from the pellets more quickly to restore balance. Conversely, if levels are only slightly below normal, the body will pull from the pellets at a slower rate.

Because of this dynamic, Dr. Varano and his clinical staff continuously evaluate dosing through regular testing. They adjust future treatments based on how each individual patient metabolizes their pellets, which is why the time between appointments can vary. This personalized and responsive approach makes pellet therapy a highly effective method for administering testosterone.

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Frequently Asked Questions About Pellet Therapy

What is hormone pellet therapy?
It is a method of delivering bioidentical hormones through tiny pellets placed just beneath the skin, where they dissolve slowly to release hormones steadily over about three to four months.
How is the pellet inserted?
During the procedure, a tiny incision is made in the skin of the upper buttock area and the pellets are placed just beneath the surface, after which they dissolve on their own.
Do pellet dosing schedules vary?
Yes. Because the body draws from the pellets at different rates depending on individual hormone needs and metabolism, dosing is adjusted through regular testing and the time between appointments can vary.
Is pellet rejection common?
The article notes that rejection of the pellets is described as extremely rare across the thousands of procedures that have been performed.
Medically reviewed by Kenneth Varano, D.O., Pennsylvania osteopathic physician license OS009028L (Pennsylvania State Board of Osteopathic Medicine) · Last reviewed Medical Director, YoungerMeMD · Board certified in Integrative Medicine (ABOIM) and Family Practice, and an Advanced Fellow in Anti-Aging, Functional and Nutritional Medicine (A4M).