Specialty Testing Guide › TruAge Biological Age Testing
Read a TruAge report from the front: the summary page sets your calendar age beside a biological age estimate, an organ-system age and a pace-of-aging score. Look at the pace-of-aging number first, then treat the pages after the summary as supporting detail, not a list of problems to fix.
Every number in the report is calculated from DNA methylation in a blood sample. None of them is a diagnosis, and a gap of a year or two from your calendar age can sit inside the test's normal measurement noise.
Key takeaways
- The summary page and the pace-of-aging score carry most of the useful information.
- Organ ages and the blood markers in the report are methylation-based estimates, not measured lab values.
- Small gaps from your calendar age are usually too small to act on by themselves.
- The report works best next to your standard bloodwork, blood pressure and history, read with a clinician.
What is in a TruAge report
TruDiagnostic, the Kentucky lab that runs TruAge, publishes a sample report. Its main sections are:
- Aging summary: your chronological age beside OMICmAge, SYMPHONYAge and pace of aging.
- OMICmAge: a single biological age, with a percentile against people of your age and sex.
- Most actionable epigenetic biomarkers: estimated markers that fall above the 80th or below the 20th percentile for your comparison group.
- SYMPHONYAge: separate ages for 11 organ systems.
- DunedinPACE: your pace of aging.
- Extra pages: estimated immune cell mix, telomere length, inflammation markers, and smoking and alcohol predictors.
Our clinic's TruAge page mentions DunedinPACE and GrimAge, and report layouts change as the lab updates its algorithms. TruDiagnostic notes on its sample report that reports processed after November 10, 2025 use an updated platform and newly trained algorithms.1 Ask our team which version you will receive.
Start with the summary page
OMICmAge is the headline biological age. The study that built it started from a mortality-risk score drawn from routine clinical lab data in about 31,000 biobank participants, then reproduced that score from DNA methylation alone.2 Several of its authors work for TruDiagnostic, which is worth knowing when you weigh the claims.
A biological age below your calendar age is reassuring, and one above it is a prompt for a conversation. Neither tells you that a specific disease is present or absent. The percentile beside it simply ranks you against people of the same age and sex in the lab's reference group.
Pace of aging: often the most useful number
DunedinPACE is a speed, not an age. A score of 1.0 means about one year of biological change per calendar year, below 1.0 is slower and above 1.0 is faster. DunedinPACE showed high test-retest reliability and was linked to later illness, disability and death in the cohorts used to develop and test it.3 For what a 0.9 or a 1.1 means in practice, see DunedinPACE explained.
Organ-system ages: read them as hints
SYMPHONYAge does not examine your organs. Each organ score is a methylation pattern trained to track ordinary clinical measures for that system. TruDiagnostic lists the kidney score as trained on markers such as creatinine and cystatin C, and the liver score on markers such as ALT and AST.4
So a "kidney age" five years older than you is not a kidney test. If it worries you, a standard metabolic panel checks kidney and liver function directly, and it is cheap and familiar to any doctor. The brain score was partly trained on memory test scores and stroke history, so it is a statistical pattern, not a scan.
The biomarker pages: estimates, not lab results
Pages listing HbA1c, glucose, hemoglobin or albumin show methylation proxies for those values. A high estimated HbA1c percentile is not your HbA1c. Compare these pages with your real bloodwork before acting on anything.
- Telomere length: the sample report itself says telomere length is largely set by genetics. See epigenetic age vs telomere length.
- Immune cell mix: estimated proportions, useful for research; a complete blood count measures real counts.
- Smoking and alcohol predictors: these reflect exposure history written into methylation.
The sample report also pairs markers with generic food and supplement suggestions. Treat those as general ideas, not a prescription.
What to focus on, and what to set aside
Focus on large gaps that show up across more than one clock, on your pace of aging, and on anything that matches your measured labs or symptoms. Set aside one-year differences, a single organ score that clashes with normal bloodwork, and small percentile shifts. Repeat measurements of the same blood sample can give different results.5 Before you read meaning into a change, check what the guide on accuracy and repeatability says.
How a clinician uses the report
TruDiagnostic describes TruAge as not a diagnostic test and positions it as an adjunct to clinical evaluation.4 A clinician reads it next to your history, blood pressure, lipids, glucose and any symptoms, and uses it to set priorities. At YoungerMeMD in Conshohocken, interpretation and planning are part of membership, and test kits are billed separately.
Your next step
If you are in Pennsylvania and considering the test, read how TruAge works near Philadelphia, or return to the TruAge guide for the full set of articles.
Frequently asked questions
Which number on a TruAge report matters most?
For most people, the pace-of-aging score and the overall biological age on the summary page. Organ ages and individual markers are best used as hints to check against standard tests.
My biological age is two years older than my real age. Should I worry?
Not by itself. A gap that small can come from measurement noise. Look at whether other clocks agree and whether your standard labs and habits point the same way.
Is the HbA1c on my TruAge report the same as a blood test?
No. It is an estimate from methylation patterns. If blood sugar is a concern, a standard HbA1c or fasting glucose test measures it directly.
Will my report look exactly like the sample?
Not necessarily. The lab updates its algorithms and layout over time, so ask our team which version you will receive.
Related reading
This article is for general education and is not medical advice. Decisions about testing and treatment should be made with your clinician. If you have severe symptoms, call 911. For a suspected poisoning, call Poison Control at 1-800-222-1222.
