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DHEA and Testosterone Testing in Women

DHEA and Testosterone Testing in Women

There is a pervasive myth in women’s health that needs to be debunked: the idea that testosterone and other “androgens” are hormones solely for men. For decades, women have been told that their hormonal health revolves exclusively around estrogen and progesterone. While those two are certainly the stars of the show, they are not the only players on the stage.

If you are a woman struggling with unexplained fatigue, a complete lack of sex drive, muscle weakness, or a “loss of mojo” that you just can’t shake, the answer might not lie in your estrogen levels at all. It might be found in your androgen levels—specifically, DHEA and testosterone.

These powerhouse hormones are critical for a woman’s vitality, mental sharpness, bone strength, and metabolic health. Yet, they are frequently overlooked in standard medical checkups. When they are tested, standard reference ranges are often so broad that significant deficiencies go unnoticed.

At YoungerMeMD, we believe in looking at the complete hormonal picture. We understand that restoring your zest for life requires balancing all your hormones, not just the reproductive ones. Through advanced diagnostics, including specialized testosterone testing women often miss out on, and comprehensive DHEA hormone tests, we can pinpoint exactly what your body needs to thrive.

The Unsung Heroes: Understanding Androgens in Women

To understand why you might be feeling off, we first need to understand what these hormones actually do. “Androgen” comes from the Greek word andros (man), which is why they are often misunderstood. In reality, women produce and require these hormones every single day, just in lower quantities than men.

Testosterone: It’s Not Just for Guys

For a woman, testosterone is the hormone of “confidence and drive.” Produced in the ovaries and the adrenal glands, it acts as a spark plug for your physiology.

  • Libido & Sexual Function: It is the primary driver of sexual desire and responsiveness.
  • Brain Health: It supports cognitive function, memory, and emotional stability.
  • Body Composition: It helps build and maintain lean muscle mass and keeps body fat percentages in check.
  • Bone Density: It works synergistically with estrogen to keep bones strong.

DHEA: The “Mother Hormone”

Dehydroepiandrosterone (DHEA) is the most abundant steroid hormone in the human body. Produced almost exclusively by the adrenal glands, DHEA is often called a “pro-hormone” because it is the raw material that your body converts into other hormones, including testosterone and estrogen.

  • Anti-Aging: It counters the effects of cortisol (stress hormone), protecting the brain and body from premature aging.
  • Immune System: It modulates immune function, helping you fight off illness.
  • Energy & Mood: It creates a sense of well-being and resilience against stress.

When these two hormones decline—whether due to aging, stress, or other factors—the result is often a profound loss of vitality.

The Decline: Why You Feel “Blah”

It is a natural biological fact that hormone levels drop as we age. However, the drop in androgens often starts much earlier than menopause. DHEA production peaks in your mid-20s and begins a slow, steady decline. By the time a woman is 50, she may produce only 20% of the DHEA she had in her youth.

This decline is often accelerated by modern life. Because DHEA is made in the adrenal glands, chronic stress can severely impact its production. When the adrenals are constantly pumping out cortisol to handle stress, they often cannot keep up with DHEA production. This leads to a state often referred to as “adrenal fatigue” or HPA axis dysfunction.

Similarly, testosterone drops as ovarian function slows down during perimenopause. Since a significant portion of a woman’s testosterone comes from the conversion of DHEA, if your DHEA is low, your testosterone will likely be low too.

The result? You don’t necessarily feel “sick,” but you definitely don’t feel “good.” You exist in a gray zone of diminished health that standard medicine often dismisses as “just getting older.”

Signs You Need a DHEA Hormone Test or Testosterone Check

How do you know if your androgen levels are the culprit? The symptoms are often physical, mental, and emotional.

1. The Vanishing Libido

This is the most common complaint we hear. It’s not just about having a low sex drive; it’s about having no drive. Women with low testosterone often report that their sexual desire has completely evaporated, and they may also experience physical issues like vaginal dryness or difficulty achieving orgasm.

2. Chronic Fatigue and Weakness

If you feel exhausted despite sleeping, or if you notice that physical tasks feel harder than they used to, low androgens may be to blame. Testosterone is vital for red blood cell production and muscle efficiency. Without it, you may feel physically drained.

3. Muscle Loss and Weight Gain

Have you noticed that your muscle tone has turned “soft” or “flabby,” even though you haven’t changed your workout routine? Testosterone helps maintain lean muscle mass. When it drops, muscle wastes away (sarcopenia) and is often replaced by fat tissue, slowing your metabolism.

4. “The Blahs” (Mood Changes)

Low DHEA and testosterone are strongly linked to lower mood, lack of motivation, and a loss of confidence. Women often describe feeling “flat”—not necessarily clinically depressed, but lacking their usual spark or zest for life.

5. Brain Fog

Androgens are neuroprotective. A deficiency can lead to fuzzy thinking, forgetfulness, and difficulty focusing on tasks.

6. Dry Skin and Hair

DHEA helps maintain skin hydration and oil production. Low levels can lead to dry, papery skin and brittle hair.

If you recognize these symptoms, it is time to look deeper. Visit our Conditions We Treat page to see how we address these interconnected symptoms.

The Other Side of the Coin: High Androgen Symptoms

While many women suffer from deficiency, others struggle with excess. Conditions like Polycystic Ovary Syndrome (PCOS) can cause elevated levels of testosterone and DHEA.

Symptoms of high androgens include:

  • Acne (especially cystic acne along the jawline).
  • Hirsutism (excess hair growth on the face, chest, or back).
  • Hair thinning or loss on the scalp (androgenic alopecia).
  • Irregular periods.
  • Aggression or irritability.

Whether your levels are too low or too high, the key to treatment is accurate data. You cannot balance what you do not measure.

Why Standard Testing Often Fails Women

If you go to a standard primary care physician and ask to have your hormones checked, they will typically order a serum (blood) test for “Total Testosterone.” While this is a start, it is often woefully insufficient for a few key reasons.

1. Total vs. Free Testosterone

Most testosterone in your blood is bound to proteins like SHBG (Sex Hormone Binding Globulin). When it is bound, it is inactive—it cannot enter your cells to do its job.

  • Total Testosterone: Measures everything, including the bound (useless) hormone.
  • Free Testosterone: Measures the tiny fraction (1-2%) that is actually biologically active.
    You can have “normal” Total Testosterone but very low Free Testosterone if your SHBG levels are high (often caused by birth control pills or thyroid issues). If your doctor only checks Total, they will tell you you’re fine, even though you have all the symptoms of deficiency.

2. The Reference Range Problem

Reference ranges for testosterone testing women receive are usually generated by statistical averages of the population. Since many women in the population are unhealthy or aging, the “normal” range is often very low. Being at the bottom 5% of the range might be “normal” for a lab, but it is certainly not optimal for a woman who wants to feel vibrant.

3. DHEA-S vs. DHEA

Blood tests usually measure DHEA-S (the sulfated form). While this is a stable marker, it doesn’t tell us how your body is metabolizing DHEA or if it is effectively converting into downstream hormones.

4. The Snapshot Effect

Hormones pulse. A single blood draw captures one moment in time. Stress from the needle stick itself can sometimes skew results, especially for adrenal hormones like DHEA.

Advanced Diagnostic Options at YoungerMeMD

At YoungerMeMD, we utilize functional medicine diagnostics that provide a high-definition view of your hormonal landscape. We don’t just want to know if you have hormones; we want to know how well they are working.

The DUTCH Test (Dried Urine Test for Comprehensive Hormones)

This is our preferred method for comprehensive hormone evaluation, including the DHEA hormone test and androgen metabolites.

Why DUTCH is Superior for Androgens:

  • It Measures Metabolites: This is the game-changer. The DUTCH test doesn’t just measure testosterone; it measures 5a-DHT and 5b-androstanediol. These are the breakdown products of testosterone. Why does this matter?
    • Some women have normal testosterone but convert it rapidly into 5a-DHT, which is a “super-potent” androgen. This woman might have normal blood levels but suffer from severe acne or hair loss.
    • Other women might have normal testosterone but do not convert it effectively, meaning they don’t get the benefits.
  • It Checks the Adrenal Context: Because DHEA is an adrenal hormone, you cannot evaluate it in isolation. The DUTCH test maps your daily cortisol rhythm alongside your DHEA. This tells us why your DHEA might be low. Is it burnout? Is it chronic stress?
  • Accurate DHEA Production: It measures DHEA-S plus its metabolites (etiocholanolone and androsterone). This gives a much more accurate picture of total adrenal androgen production than a blood test alone.

Serum (Blood) Testing Done Right

We do use blood testing, but we do it comprehensively. We check:

  • Total Testosterone
  • Free Testosterone (calculated or measured directly via dialysis method)
  • SHBG (Sex Hormone Binding Globulin)
  • DHEA-S
  • Estradiol and Progesterone (for context)

By combining these methods, we ensure no stone is left unturned. You can learn more about our specific testing panels on our Advanced Specialty Testing page.

Interpreting Your Results

When we review your testosterone testing women panel or your DHEA hormone test results, we are looking for optimal ranges, not just normal ones.

The “Cortisol Steal” Phenomenon

One common pattern we see in testing is high cortisol combined with low DHEA. This indicates the “Cortisol Steal” (or pregnenolone steal).
Your body is prioritizing survival (cortisol) over vitality (DHEA/Testosterone). In this case, simply giving you testosterone might not work well if we don’t also address the underlying stress that is draining your tank.

The SHBG Trap

We also look closely at SHBG. If SHBG is high, it acts like a sponge, soaking up all your free testosterone.

  • Causes of High SHBG: Birth control pills, hyperthyroidism, extreme low-calorie dieting, and aging.
  • Causes of Low SHBG: Insulin resistance, obesity, and hypothyroidism.
    Understanding SHBG allows us to treat the root cause. For example, if insulin resistance is driving your SHBG down and causing high free testosterone (PCOS type symptoms), we treat the insulin, not just the hormones.

Treatment Options: Restoring Your Vitality

Once we have identified an imbalance through a DHEA hormone test or testosterone panel, we create a personalized treatment plan. At YoungerMeMD, we prioritize safety and efficacy.

1. DHEA Supplementation

If you are low in DHEA, supplementation can be a miracle worker. However, it must be dosed carefully.

  • Start Low: Women are very sensitive to DHEA. Too much can cause oily skin or acne. We typically start with small, physiological doses (e.g., 5mg – 10mg).
  • Monitor Conversion: We re-test to ensure the DHEA is converting into testosterone and estrogen as desired, rather than stockpiling or converting into inflammatory metabolites.

2. Testosterone Replacement Therapy (TRT) for Women

Yes, women can and do benefit from testosterone therapy.

  • Bioidentical Cream: This is the most common method. A small amount of bioidentical testosterone cream is applied to the skin daily. It allows for easy dose adjustments.
  • Pellet Therapy: We offer EvexiPEL hormone pellet therapy. A tiny pellet (about the size of a grain of rice) is inserted under the skin. It releases a steady, consistent dose of bioidentical testosterone over 3-4 months. This avoids the “rollercoaster” effect of daily creams and ensures 24/7 symptom relief.
  • Safety First: We monitor your labs closely to ensure levels remain within the optimal physiological range for women, avoiding side effects like hair growth or voice changes.

Learn more about our hormone therapies on our Hormone Health & Sexual Wellness page.

3. Lifestyle Optimization

You cannot out-supplement a bad lifestyle. To support healthy androgen levels naturally:

  • Resistance Training: Lifting weights is the single best form of exercise for boosting testosterone and DHEA naturally. It signals your body that you need to be strong, prompting hormone production.
  • Stress Management: Since stress lowers DHEA, practices like meditation, yoga, and adequate sleep are medicinal.
  • Dietary Fats: Steroid hormones are made from cholesterol. A diet extremely low in healthy fats (like avocados, nuts, and olive oil) can starve your body of the raw materials needed to make hormones.

4. Adrenal Support

If your DHEA hormone test showed adrenal dysfunction, we support the glands with adaptogenic herbs (like Ashwagandha, Rhodiola, or Ginseng), B-vitamins, and Vitamin C.

The Safety Question: Is It Safe for Women?

A common fear is that taking testosterone or DHEA will make a woman look masculine or cause “roid rage.” This is a misunderstanding based on the abuse of synthetic anabolic steroids by bodybuilders.

At YoungerMeMD, we use bioidentical hormones. These are molecularly identical to what your body makes. We use doses that mimic healthy, youthful production—not supraphysiological doses. When monitored correctly by a specialist, the risk of masculinizing side effects is extremely low.

Furthermore, maintaining optimal testosterone levels is actually protective for women. It protects the breasts, bones, and heart. The danger often lies in having levels that are too low for too long, leading to frailty and metabolic disease.

The YoungerMeMD Difference

Navigating the world of testosterone testing women needs and DHEA hormone test interpretation requires expertise. Most general practitioners are not trained in the nuances of functional hormone optimization.

We operate on a membership model that prioritizes the patient-provider relationship.

  1. Time: We spend 60 minutes in your initial assessment, listening to your full story.
  2. Depth: We use the most advanced testing available (DUTCH, advanced lipid panels, inflammatory markers).
  3. Holistic View: We don’t treat numbers; we treat people. We look at how your thyroid, gut, adrenals, and sex hormones are all interacting.
  4. Continuous Care: Hormones change. Your protocol shouldn’t be static. We monitor and adjust your plan as your body heals and evolves.

To see what our members have to say about their experience, visit our Reviews page.

Don’t Settle for “Normal”

You know your body better than anyone else. If you feel tired, weak, or lacking in drive, do not let anyone tell you it is “all in your head” or just a part of aging.

Low DHEA and testosterone are treatable conditions. You have the option to feel vibrant, strong, and energized again.

If you are ready to get answers and stop guessing, we invite you to take the first step.

Book Your Assessment today to schedule your comprehensive evaluation.

Or, explore our Home Page to learn more about our philosophy of living younger, better, and longer.

Disclaimer: The content provided in this blog is for informational purposes only and is not intended as medical advice. Always consult with a qualified healthcare provider for diagnosis and treatment of any medical condition.

 

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About Dr. Kenneth Varano, D.O.
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Dr. Kenneth Varano is one of the most distinguished voices in Anti-Aging, Functional, and Preventive Medicine today. As the founder of YoungerMeMD, Dr. Varano brings over 30 years of clinical experience in transforming how people age, using science-backed, patient-focused strategies that restore balance, vitality, and health longevity.

About Barbara Dougherty
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Dr. Barbara Dougherty is a Board-Certified Family Nurse Practitioner and Certified Menopause Practitioner (MSCP) specializing in optimizing hormones, and improving cardio-metabolic health. 

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